Victor Lindelof also played 90 minutes for Sweden in midweek after missing United's defeat to Newcastle last time out in the Premier League.
David de Gea needs no introduction, throughout the Lancashire team's decline, the Spaniard has been the one consistent performer and they would be a lot worse off if it wasn't for his heroics.
Solskjaer could welcome back Aaron Wan-Bissaka and Anthony Martial but that will come as little consolation, as Paul Pogba is out, while Luke Shaw, Daniel James and Jesse Lingard all remain major doubts.
Woodward has said he and the United board give Solskjaer "100 per cent" backing given the situation he inherited with a squad who were not fit enough for the style which he wanted them to play. "Meanwhile, Pogba had a scan after the Arsenal game [at the end of last month] and maybe needed rest for a few weeks in a boot so hopefully, he won't be too long, but he won't make this game, no".
"It's a good decision for the manager because everyone wants to have the best and I think we are here - two No1s, ' said Adrian".
The two injuries are a blow for Solskjaer's side, who sit 12th in the Premier League, 15 points behind leaders Liverpool, who have won all eight of their league matches thus far.
"Hopefully, Aaron and Anthony will last the training this week and be available for selection", the Norwegian coach added.
I'm not going to go down the route of bringing players in on big contracts and big fees if they're not the right ones for the whole group and for the future.
"We're planning and we're looking".
Los Blancos officials are well aware that United hold an interest in the German midfielder, having enquired about him in the past and hope by offering the player and a substantial cash adjustment it could help to get the deal done.