Chelsea, meanwhile, fell further behind the top Premier League clubs with a 2-2 draw at Stamford Bridge against Sheffield United.
Aguero is setting the pace with six goals to his name following his brace against Brighton and the Man City striker is the 7/2 favourite in the Betfair Sportsbook's Top Goalscorer market, just ahead of Mo Salah (three goals) at 4/1 and his City strike partner Raheem Sterling (five goals) at 9/2.
The Reds made it four wins from four by beating Burnley 3-0 on Saturday for their 13th straight win, eclipsing the club mark set between April and October 1990.
After one shot hit off the woodwork and Mohamed Salah failed to convert a one-on-one opportunity, Liverpool scored in the 33rd minute courtesy of a lucky bounce when a cross by Trent Alexander-Arnold deflected off of Burnley forward Chris Wood, traveled high in the air and entered the goal out of the reach of net minder Nick Pope.
Firmino then added a late third as Liverpool also equalled a club record with their sixth consecutive away win.
Last season, Man City won the Premier League title on the last day of the season after facing serious competition from Jurgen Klopp's men.
Burnley then played a huge part in their own downfall moments later when Ben Mee gifted possession to Firmino inside the hosts' half.
Not surprisingly, Man Utd [2.62] and Chelsea [3.6] drifted in the Top 4 Finish market following their failures to take all three points on Saturday, and it's Tottenham [1.6] and Arsenal [1.9] that are fancied along with Man City and Liverpool to finish in the top four this season.
City's 4-0 victory came at a cost as influential center-back Aymeric Laporte was stretchered off with a knee injury that looks set to rule him out for the foreseeable future.
Daniel James had given the visitors the flawless start with his third goal in four appearances for United, but Jannik Vestergaard headed home an equaliser just before the hour mark.
Third-placed Leicester continued their excellent start to the season with a 3-1 win over Bournemouth, with Jamie Vardy involved in all the home team's goals.
"We have to take responsibility, we allowed that to happen".
Tottenham looked on course for their first league win away from home in eight attempts when goals from Christian Eriksen and Harry Kane put Mauricio Pochettino's men 2-0 up over north London rivals Arsenal.
"If we can't go on and get a third goal that's something we have to work on, this is the Premier League, it's ruthless".
Leicester regained the lead four minutes before the break when Youri Tielemans stabbed home Vardy's cross.
West Ham claimed a second successive league win with a 2-0 home victory over Norwich.
At the other end of the table Newcastle shortened to [2.66] in the Relegation market after playing out a 1-1 draw with Watford [3.6] at St James' Park.