Taking Smith's runs out of the equation should, in theory, give England the edge, but there is hope for Australia in Smith's likely replacement Labuschagne, who scored a gritty 59 as Australia saw out the draw at Lord's. Paine said Australia expected more of the same fiery bowling from Barbados-born fast bowler Archer in the third Test.
Smith and team-mates David Warner and Cameron Bancroft have been roundly heckled during the current Ashes series for their involvement in the ball-tampering scandal in South Africa previous year, for which Smith and Warner received 12-month bans and Bancroft a nine-month suspension.
In his absence, the new rule stipulating that teams can bring in a full substitute in case of a concussion suffered by one of their players, was put into effect for the first time and Marnus Labuschagne was brought into the XI.
"I think you're always preparing for the next game and what you think you're going to face", Paine said. "He seems to enjoy getting hit on the head. Marnus has handled himself exceptionally, his innings was unbelievable after that happened".
Initially, Smith passed a concussion test and was allowed to return to the field and complete his innings, but his condition worsened the following day. Clearly, they're huge shoes to fill.
Meanwhile, England captain Joe Root said he would have no qualms about a player withdrawing from a match because of concussion.
"When we followed the protocols, he was probably a couple of days off being fit to be selected".
World Cup-winner Archer's Test debut, which yielded five wickets, also featured a compelling duel with Smith.
"It's not unlike England losing James Anderson, actually", he said. "I think England still have a lot of worries in their top order and with three Tests to go and Australia leading 1-0, England have to win at least two".
The fact that we've got it now in worldwide cricket goes to show how much has gone into it.
"We have to make sure our senior players and the younger guys step up and fill what are nearly unfillable shoes because he's the best player in the world".