The 32-year-old, five-times a victor of the singles at the prestigious Wimbledon warm-up event, delighted a large evening centre court crowd with some fluent shot-making as he and Spanish veteran Lopez beat top seeds Juan Sebastian Cabal and Robert Farah 7-6 (5) 6-3.
The 37-year-old had spent just shy of five hours on court playing three different matches on Saturday, getting through to the singles final before returning to what this week has seemed far more important, the doubles.
However, Murray is not reinventing himself as a doubles player.
Making my return at Queen's was a special moment; it was really nice being back on a tennis court and I enjoyed it.
"I started to play better in the second and have zero discomfort in my hip which would not have been the case past year, I would have been aching and throbbing". A year ago when I came on the court, I was quite emotional and stuff, because I hadn't played for a long time but didn't get loads of enjoyment out of the match.
"I felt quite relaxed in the build-up, but we said as we were walking on to the court that we were starting to feel a bit nervous", he said.
Tennis players are used to waiting, but after five months out it was hardly an ideal welcome back for Murray as he patiently waited for the four preceding centre court matches to play out.
He has been moving freely alongside Lopez this week and was clearly fired-up on Sunday as he won his first doubles title since 2011 when he partnered brother Jamie in Tokyo.
"Like, I just won the doubles here with Feli, you know, with a metal hip".
I might have had to play against those people asking me how I was, so I wasn't going to tell them that my hip was killing me and then play them the following day. We played a good match.
But when he did step out onto the grass, he looked a different player to the one that was limping around for the best part of two years.
Two first-round matches have been held back until Thursday, those between Nick Kyrgios and Roberto Carballes Baena, and Grigor Dimitrov and Felix Auger-Aliassime. "I don't know how long it will take to get to that level, but hopefully not too long". I thought some of the calls were outrageous today. I had a conversation with them in Miami after I got fined again for their mistake.
"But then I think I started to play better in the second and started to serve a bit better, see the returns a little bit better". They just think it's a joke because nothing happens to them after the match.