Arsenal fans may feel they have to take a lead into the second leg, such is their away form.
"We're defending badly at the moment, even when it was 11 against 10, and that means we can not control the game", said Ancelotti.
They have won just once on the road in the league, at relegated Huddersfield, since late November but Sokratis denied it was becoming something of a mental hurdle.
"The performances are helping us also".
Meanwhile, Pierre-Emerick Aubameyang, who started on the bench in Arsenal's last two fixtures - Sunday's 1-0 defeat at Everton and the 2-0 victory over Newcastle - has been struggling with illness.
Tottenham are a point ahead of Arsenal in third place.
"The first reason (Aubameyang has not started) is because he had a small problem and he has taken antibiotics for his illness", explained Emery.
Forwards Lorenzo Insigne and Simone Verdi have been included in Napoli's squad following recent injury absences.
Arsenal and Napoli have faced off just twice before in Europe - home and away in the group stages of the Champions League in 2013-14.
Arsenal - who are now fifth in the table - have failed to finish in the Champions League spots in the last two seasons.
Winning the competition would automatically qualify them for next season's Champions League - a tournament they haven't been a part of for two years.
Manchester United who are in sixth position with 61 points also had a free weekend until they play their week 33 match at Old Trafford against West Ham in the coming week. I don't get the decision to play Mohamed Elneny and Henrikh Mkhitaryan.