The first draft deal with the European Union was rejected in January by 220 votes, and while last night's margin was smaller it was still a crushing 149-vote defeat for the Prime Minister.
Some of them believe it's time now to go hell-for-leather to leave without an overarching deal but move to make as much preparation as possible, and fast.
Speaking after the defeat, she said MPs would have to decide whether they want to delay Brexit, hold another referendum, or whether they "want to leave with a deal but not this deal". She said she would allow Conservative MPs a so-called free vote on Wednesday when parliament will vote on whether it supports or rejects leaving the European Union without a deal.
May told Bone this was not realistic: "The EU have made it clear there will be no agreement without a withdrawal agreement, and that includes what we have already negotiated on citizens' rights, a financial settlement and a Northern Ireland protocol".
"Once again, she's putting her party's interests ahead of the public interest", said a Labour Party spokesperson.
Labour MPs indicated they meant to vote against a no-deal Brexit on Wednesday.
Ed Miliband, Doncaster East MP; Sarah Champion, Rotherham MP; John Healey, MP for Wentworth and Dearne, and Barnsley MP Dan Jarvis voted against the deal.
"This fiasco can not go on - is absolutely clear that there must be an extension to article 50 to allow the public to vote again".
But Ms Smith said: "Yesterday Theresa May presented the same deal before MPs again, and again I voted against it".
Heidi Allen MP
"Ultimately, I do not believe that the United Kingdom will be able to find an agreeable solution to Brexit within a "short time" - we will need a minimum extension of a year".
Downing Street has so far not laid out any groundwork for an extension.
Opponents of Brexit have warned that leaving without a plan will throw Britain's economy into turmoil, while backers have dismissed those concerns as exaggerated.
Theresa May's Brexit strategy was hit by a devastating blow after the House of Commons rejected her EU Withdrawal Agreement by an overwhelming majority for the second time.
"I have said this would be necessary since November".
Shadow business secretary Rebecca Long-Bailey told BBC News Parliament would increasingly "set the agenda" if the government was not in control of events.
Mr Zeichner slammed the government for "recklessly wasting yet more time in order to force a false binary choice" over Brexit.
"I might sound arrogant but I thought it was very important to think it through: 'Can I cope with it?"