Thomas Mueller, Mats Hummels, and Jerome Boateng all started for Bayern, days after being dropped by Germany coach Joachim Loew. Both teams have 57 points on the season.
On Friday: Serie A: Juventus 4 (Kean 11, 39, Can 67-pen, Matuidi 71) bt Udinese 1 (Lasagna 84).
For Lewandowski, it ensured the Polish striker overtook Claudio Pizarro's record goal tally.
Robert Lewandowski has become the top foreign goalscorer in Bundesliga history.
"I'm very satisfied with the match, I liked the way we played, we were never in trouble", he told the club's official website.
His second league goal came in what has been a frustrating season due to injury and the emergence of English youngster Jadon Sancho.
Bayern ran riot in Munich as Robert Lewandowski scored twice, leaving him with 20 goals in 17 league games against Wolfsburg, while Serge Gnabry, James Rodriguez and Joshua Kimmich also netted. It might yet go right down to the wire but with Bayern now leading the table, few would bet against the champions winning what would be their seventh title in a row.
Arnold - whose Wolfsburg side travel to the Allianz Arena on Saturday - does not believe a seventh consecutive Bundesliga title for Bayern would be healthy for the game in Germany, and he therefore wants to see Lucien Favre's side triumph this season.
Borussia Dortmund's five-month spell at the top of the Bundesliga is over despite a 3-1 victory over relegation-threatened Stuttgart at Signal Iduna Park.
Pizarro had always been the top-scoring foreign player in the league but has now been overtaken for the first time by Lewandowski.