She also weighed in on those red berry Christmas trees unveiled at the White House earlier this week, which have sparked comparisons to blood.
More than 40 red topiary trees line the East colonnade as part of the holiday decorations at the White House.
"We are in [the] 21st century and everybody has a different taste".
"I think they look fantastic", Trump said.
First lady Melania Trump is calling the opioid epidemic the "worst drug crisis in American history" and says she is struck by how it has touched the lives of so many people.
"When you're first lady, there's no free time", she added.
But if Trump thought this year's decorations would escape ridicule, she's wrong.
Another subject was social media etiquette, a cornerstone of her "Be Best" campaign (along with opioid use and well-being), with Melania remarking that it's important to be "respectful and kind". She said Barron doesn't engage in social media because he's "all into sports".
Watch Melania Trump's full interview here.
"I hope everybody will come over and visit it", she said.
"When I took on opioid abuse as one of the pillars of my initiative 'Be Best,' I did it with the goal of helping children of all ages", she said.
This year's theme is a little warmer than last year's "dead branches and barren landscape" look that had Twitter users comparing it to "The Nightmare Before Christmas" and "The Shining". She stressed the importance of getting rid of the stigma associated with opioid or other substance addiction.