Son Heung-min added a third early in the second period with the pick of the goals, making the most of some bad Chelsea defending in doing so, and though substitute Olivier Giroud bagged a late consolation, the Blues' unbeaten start to the season ended in their 19th match under Maurizio Sarri.
Chelsea fall to their first competitive defeat of the Maurizio Sarri era as they are humbled 3-1 by Tottenham Hotspur at Wembley Stadium.
Here's how we rated the Blues.
He was then fortunate to avoid a booking for tangling with Kane at a Chelsea free kick, when he left the Spurs man with a ripped shirt that offered cast-iron evidence of his cynical grappling.
Considering Tottenham's disappointing record against the other top four teams - two losses at home to Man City and Liverpool - you would expect Mauricio Pochettino to be willing his team to a much-needed victory in this department.
There's a new second place side, at least until Sunday, as Eintracht built a three-goal lead starting with a first minute goal from Canadian midfielder Jonathan De Guzman.
Willian had a strike deflected over as Chelsea showed signs of life early in the second period, only for Son to bring the house down.
And Alli says Tottenham could have eased off, but did not.
Kane and Alli should have added further goals before substitute Giroud found scant consolation for a well-beaten Chelsea.
But what pride they should take in their team, anyway.
The Tottenham boss suggested that matches against Chelsea were now the club's largest derby showdowns, due to Arsenal's disappointing league performances in recent years.
Even so, Sarri, a personal friend of Guardiola, believes there is still a gap to close before Chelsea can challenge City for the title.
Son's dramatic intervention ended Watford's unbeaten run of five games and pushed Spurs up to third in the table. This was a display right out of his Brazil v Germany in the 2014 World Cup semi-final playbook.