Last season, Guardiola said the loss of Mendy had cost his side attacking width on the left and used Leroy Sane as his preferred winger on that side. "We lost, but we have the second game at Old Trafford and we will see".
Mendy underwent knee surgery in Barcelona last week - on the opposite knee which caused him to miss most of last season - and will be out of action for "10-12 weeks".
City are already without Kevin De Bruyne, yet to return to first-team training, while Bernardo Silva has been ruled out of the trip to the London Stadium after picking up a minor injury while on global duty with Portugal.
There is also doubt over whether the Portugal worldwide will be available for Tuesday's Champions League clash at Lyon.
"Bernardo Silva can not play this weekend", he said.
"I love to read, but I don't read".
The Fiver: sign up and get our daily football email. "I remember when I arrived in England it was a top four, now it is a top six, so every year it is more hard", the Belgian said to "Sky Sports".
"Everybody has dreams and when I was a little boy I had dreams". I said maybe in the future I would like (international management).
Managers are not allowed to discuss officials before a match.
Undefeated defending champions City now hold a two-point lead over a similarly unbeaten Liverpool, with Maurizio Sarri's Chelsea - who are also yet to suffer a defeat - a further two points behind in third spot.
Guardiola says he is an admirer of the veteran Chilean coach. Interestingly, England manager Gareth Southgate, who has studied the impact of overseas footballers on homegrown talent during his career at the FA, is doubtful about the effect such a limit would have, and admits that there is division on the matter within the organisation itself. We have a young squad, young players I have everything [including] good facilities.
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