The president later tweeted that Mr Mueller and "his gang of Democrat thugs" were destroying people, and blamed social media tech giants for unfavourable coverage towards his administration and the Republicans.
House Democrats are launching an investigation into Acting Attorney General Matthew Whitaker's involvement in World Patent Marketing, where he served as a paid adviser for the Florida company shut down by a federal judge earlier this year and fined nearly $26 million for allegedly running an invention-promotion scam.
Whitaker's appointment following the firing of Jeff Sessions last week has been slammed by Democrats as potentially unconstitutional, as well as an effort to undermine special counsel Robert Mueller, whose investigation Whitaker has publicly criticized. Check out how biased Facebook, Google and Twitter are in favor of the Democrats.
It is unclear what was behind his latest comments and Mr Trump did not provide any evidence for his claims.
Elie Honig, a former federal prosecutor for the Southern District of NY, speculated to Bertrand that "prosecutors had some sort of "time to get real" conversation with someone implicated in the investigation, which was then relayed to Trump by defense attorneys". Mueller appears to be interested in Stone's alleged contact with Julian Assange concerning Wikileaks' release of leaked Hillary Clinton campaign emails ahead of the election.
There's also the possibility that the president knows something new - either passed along from his lawyers or allies under investigation, or from his newly appointed acting attorney general, who the New York Times referred to in September as the White House's "eyes and ears" in the justice department. "I think my only crime was that I support Donald Trump".
Despite calls from Democrats for Whitaker to recuse himself from overseeing the Mueller probe, Graham separately told Fox News that Whitaker doesn't feel the need to do so.
The barrage comes as Trump's legal team is believed to be finalizing written answers to Mueller, concerning questions about whether the Trump campaign colluded during the 2016 campaign.
The Associated Press reported this week that Trump advisers are concerned that Mueller has been stealthily compiling information and could soon issue new indictments (it has so far produced 32 criminal charges) or a highly critical final report.
It has been established that senior members of Mr Trump's team met Russian officials, while several of these meetings were not initially disclosed.