His family say they have not heard from him since he left Interpol HQ in the French city of Lyon for a trip back to China on September 29, police sources say. "This is a matter for the relevant authorities in both France and China", Interpol said in a statement.
In an extremely curious occurrence, French police are now busy searching for the Chinese president of Interpol after he was reported missing by his wife.
Police in France have opened an investigation into the disappearance of Interpol president Meng Hongwei.
Meng, 64, has been the president of Interpol for nearly two years.
"He left Lyon for China last week".
His family members last heard from him before he left for China on September 29.
When Meng was named Interpol's president in November 2016, human rights groups expressed concern that Beijing might try to leverage his position to pursue dissidents overseas.
Meng's duties in China would have put him in close proximity to former leaders, some of whom had fallen afoul of President Xi Jinping's sweeping crackdown on corruption.
Meng Hongwei, the director of Interpol, is reportedly missing.
It was not clear whether Mr Meng had travelled to China on official business or for personal reasons. He was due to serve until 2020. Interpol's day-to-day operations are overseen by its secretary general.
In July a year ago, Meng gave a speech on the importance of cracking down on cybercrime which observers said might reflect China's views on the issue.
According to Interpol's website, in May he delivered a speech in Ireland in which he discussed the changing face of global crime and the need for Interpol to remain above political considerations.