Messi's arrival changed the game in Barcelona's favour but Ernesto Valverde will rue more points dropped in La Liga as he switches attention to the midweek clash with Tottenham in the Champions League.
The debate about Barca's dependence on Messi is not a new one, but it resurfaced on Saturday when the Argentine came off the bench to help them salvage a point at Camp Nou as their winless run extended to three games.
Leganes climbed off the foot of the table as they fought back from an early goal down to beat Barcelona 2-1 at Butarque on Wednesday.
Wissam Ben Yedder volleyed home a third to wrap up the game before half-time - his sixth goal in three games.
"If you are a team who are used to winning and you do not, you should congratulate the other team but Barcelona did not do that to us".
"Sometimes it's hard to explain what happens in a game".
"Of course we need the points", Valverde said, adding, "any team needs the points but for us even more so, because every team Barcelona loses, there is an quake".
Far from their best in terms of quality of football, in the fluidity of their offensive play, the capacity to create chances and above all, in defensive solidity. "That's five points in three days gone and it's hard to explain".
Oscar Rodriguez, a former member of Real Madrid's youth teams, who is on loan with Leganes, took advantage of Pique's uncharacteristic mistake to score the 53rd-minute victor.
Barca struggled to get into the contest in the second half as mistakes continued to creep into their game, although they went close to equalising 10 minutes from time.
Sevilla were relentless throughout the first half and after Franco Vazquez hit the bar, striker Wissam Ben Yedder scored in the 39th minute for his sixth goal in a week to stun Real, who suffered their first loss under manager Julen Lopetegu.