It includes midfielder Ruben Loftus-Cheek, a player who has only played 22 competitive minutes for his club Chelsea since appearing at the World Cup for the Three Lions.
Southampton goalkeeper Alex McCarthy is the man chosen to replace the injured Nick Pope as third-choice goalkeeper, but Southgate has kept faith with 18 of the 23-man squad that led England to the World Cup semifinals.
However, there's still no place for the likes of Joe Hart, Chris Smalling and Jack Wilshere.
England hosts Spain in the UEFA Nations League on September 8 and Switzerland in a friendly three days later.
Gareth Southgate admitted the pool of England players available for selection is dwindling as Premier League clubs continue to overlook their young stars.
Joe Gomez, who missed the tournament through injury, returns to the fold - as do Adam Lallana and James Tarkowski, who were both on standby ahead of the squad's departure for Russian Federation.
England have undergone several reviews of the state of the game following World Cup disappointments and while Southgate is clearly pleased there is no need for a structural overhaul this time, he feels that the danger of young players not getting playing time needs to be looked at. Others haven't really had the opportunity to force themselves ahead of those guys. The former Arsenal defender also claimed that he suggested the Englishman's name to the Gunners, much before he was snapped up by Manchester United.
"In this moment he is feeling the good results of the hard work and the good results of many people that work with him and try to make him a proper football player because a proper football player is a player of consistency", Mourinho told a news conference on Friday.
"We're aware of the excitement around some other young players but we think it's a bit early for them". I did that myself for a few years. It was great that we were able to have mature conversations about that. We also wanted some continuity. "The door's certainly not closed".