" 'Remember what I previously said - Obama will someday attack Iran in order to show how tough he is, ' " Kimmel added, quoting a Trump tweet from September 2013.
Regularly suspected of favouring regime change in Iran, Mr. Pompeo refused to distinguish between moderates and radicals at the heart of the Islamic Republic.
An Iranian Foreign Ministry spokesman said, "Such policies will unite Iranians who will overcome plots against their country". He said Iran has a leading position in the Gulf and the Strait of Hormuz, a major waterway for oil shipping.
"He's much more impulsive than he is strategic".
James Jay Carafano, a national security specialist at The Heritage Foundation, said the president was expressing himself to Tehran "in a uniquely Trumpian manner".
"Drive them out of Syria, don't cut a deal with Russian Federation to give them Syria".
"The president has been, I think, pretty strong, since day one, in his language towards Iran".
"He was responding to comments made from them, and he's going to continue to focus on the safety and security of American people", she said.
It is hard to recall the last time the leaders of a regime were compared to the "mafia", as Pompeo did in his description of the clerics sitting on the throne in Tehran.
Mr Trump this year pulled the USA out of the global deal meant to prevent Tehran from developing a nuclear weapon and ordered increased American sanctions.
The other signatories to the deal have vowed to stand by it.
The Trump administration has launched an offensive of speeches and online communications meant to foment unrest and help pressure Iran to end its nuclear program and its support of militant groups.
US President Donald Trump speaks to reporters after signing a proclamation declaring his intention to withdraw from the JCPOA Iran nuclear agreement in the Diplomatic Room at the White House in Washington, US, May 8, 2018.
Tehran is already aware of what is coming from the administration as consequences of Trump's May withdrawal from the 2015 nuclear accord take shape.
"We are asking every nation who is sick and exhausted of the Islamic Republic's destructive behavior to join our pressure campaign".