Belgium expect to be up against a defensive Tunisia, who will rely on quick counter-attacks.
They remain among the favourites at this year's World Cup and beat Tunisia 5-2 to maintain their winning start.
Hazard netted twice, as did Romelu Lukaku, with Michy Batshuayi adding a late effort as Roberto Martinez's men strolled to a 5-2 success in Moscow to move to the brink of qualification for the last 16.
Lukaku is joint tournament top scorer with Portugal's Cristiano Ronaldo on four goals, and with seven goals Belgium's most successful scorer at World Cups and Euros overall, one more than Jan Ceulemans.
Tunisia now exit the tournament after two losses, but they can leave encouraged after scoring twice against the Belgians, with Dylan Bronn and Whahib Khaziri getting on the scoresheet.
The Chelsea star sprinted onto De Bruyne's lofted pass, held off two defenders, rounded keeper Ben Mustapha and tapped home Belgium's fourth goal in the 51st minute.
Hazard hit the ball low and left past Tunisia goalkeeper Farouk Ben Mustapha to give Belgium the lead.
The goal means Lukaku became only the fifth Belgium player to score in back-to-back World Cup matches, with Marc Wilmots the last to do it when he scored in every group-stage game in 2002.
England will await the result of this match with a great deal of interest with their Group G encounter with Panama on Sunday.
Although it remains guesswork at this stage, the pool winners could end up facing the victor of Brazil and Germany in the last eight, while the runners-up may get one of Mexico, Sweden or Switzerland assuming they dispense with the victor of Group H in the last-16.