"Together, Winfrey and Apple will create original programs that embrace her incomparable ability to connect with audiences around the world", Apple said in a statement.
According to The Hollywood Reporter, the deal includes films, television shows, smartphone applications and books that can be distributed through Apple.
Winfrey is the CEO of the Oprah Winfrey Network (OWN) which is a US-based television channel owned by Harpo Studios and Discovery Inc.
The big picture: Apple has reportedly landed a dozen TV projects since last October but none approach the magnitude of its latest signing. Now, Oprah has officially not only taken a side, but she's signed a contract as well - with competitor Apple TV.
AT&T on Thursday closed an $85 billion deal for media-entertainment giant Time Warner, giving the telecom-broadband group a strong position in both content and delivery.
I hear her OWN exclusivity is for ad-supported cable only, and she is allowed to produce and appear on-camera on other platforms on a limited basis. Through her Harpo Films, she has produced several Academy Award-winning features including "Selma", which was directed by DuVernay.
Whether Winfrey herself will appear in the shows she'll produce is not yet known, though she is expected to host and interview guests, as she's so deft at doing. In addition to the previously mentioned morning show drama, the streamer is prepping shows like a reboot of Steven Spielberg's "Amazing Stories," a psychological thriller series from executive producer M. Night Shyamalan, the true crime podcast drama series "Are You Sleeping?" starring Octavia Spencer and Aaron Paul, and an Emily Dickinson series starring Hailee Steinfeld among many others.