Kane scored his 26th Premier League goal of the season in Tottenham's 1-1 draw with Brighton on Tuesday night but remains four goals behind Liverpool's Mohamed Salah in the race for the Golden Boot.
But the visitors had little time to celebrate, with Gross beating Lloris from the spot after Serge Aurier clumsily felled Jose Izquierdo.
The result ensured the Seagulls are eight points clear of the relegation zone, and the Cameroon worldwide has asked his side to "keep fighting" as they aim to maintain their Premier League status. "You always have a chance in football so we got a point today and we have to keep going".
He said: "After the loss to City, we finished very late, some players needed to rest, some players needed to stay on the bench and I think we have a strong squad".
"In reality, you put Tottenham on the same level as the top four or top six because the last few years we have been there".
Kieran Trippier, Mousa Dembele, Eric Dier and Erik Lamela were also taken out of the starting XI, but they did make the bench.
Pochettino defended his selection, saying: "We were thinking of giving the team fresh legs because Saturday's game against Manchester City was tough mentally and physically".
And former Arsenal striker Wright said on The Debate: "They need to spend".
"From when I first signed there to now, Tottenham are a complete different club".
'Everyone is ready to play but Brighton was a very hard opponent and we need to give credit to them'.
Albion top-scorer Glenn Murray has missed two costly spot-kicks this season and he stood aside to allow German midfielder Gross to convert from 18 yards. It is actually a league fixture.