Arsenal's 2-1 defeat away at Newcastle means the Gunners are still yet to accrue a Premier League point away from home in 2018. Wenger criticised the decision after Arsenal were denied a possible penalty for handball in the first half of Sunday's 2-1 loss.
Premier League clubs voted on Friday that the much-debated video assistant referee system will not be used in the competition next season as testing continues in cup games. "We didn't put our chances to bed and made unbelievable mistakes".
On their worrying away form, Wenger said: "Of course it's a concern". It doesn't make sense.
Newcastle's winning margin could have been greater, but Kenedy's audacious effort came back off the woodwork late on.
Matt Ritchie then netted his third goal of the season to secure Newcastle's win and take them to 41 points for the season.
Full-back Calum Chambers passed up an opportunity to restore the Gunners' lead six minutes before the break when unlike Lacazette, he could not stretch far enough to direct Mustafi's headed cross on goal. Just moments after he was left writhing on the turf following a crunching challenge from Kenedy, Lacazette exacted revenge.
Alex Iwobi nearly doubled Arsenal's lead moments later with a stinging strike that forced a good save from Martin Dubravka.
The Gunners though always seem to shoot themselves in the foot and that is exactly what they did in the 29th minute as Ayoze Perez finished off a cross at the near post after getting away from his marker to level proceedings for the home side.
Arsenal: Cech; Chambers (Maitland-Niles, min. 78), Mustafi, Holding, Monreal; Elneny, Xhaka, Willock (Welbeck, min. 68); Iwobi (Nketiah, min. 86), Aubameyang, Lacazette. It had no effect on Newcastle's Premier League status, nor on Arsenal's European qualification.
It was also Arsenal's fifth defeat away from home in the league.
Ritchie scored the victor against Manchester United on February 11 that kickstarted Newcastle's surge to safety and he did the same here, running onto Perez's flick off Islam Slimani's header to beat Petr Cech from 12 meters (yards).