Atletico, the 2010 and 2012 Europa League winners, have now won their past nine matches at the Wanda Metropolitano. Atletico pessimists may concern themselves with Filipe Luis's definite and Juanfran's possible absences but Jorge Jesus' Sporting will need their attacking triptych of Dost, Bruno Fernandes, and Gelson Martins to produce two stellar performances, particularly in the second-leg at the Estádio José Alvalade, if they are to have even a remote chance of getting to the Semi-Finals.
The Spain global has since sat out LaLiga fixtures against Villarreal and Deportivo La Coruna but returned to training with the first-team squad earlier this week.
Played the first matches of the 1/4 finals of the Europa League.
Koke put his side ahead on just 22 seconds, slotting home after Diego Costa robbed dawdling Sporting defender Sebastian Coates.
The French global has 16 goals in his last 15 matches for Atletico in all competitions.
Aleksandr Golovin curled home a wonderful free-kick after haphazard defending from Shkodran Mustafi and Laurent Koscielny to level six minutes later.
"We know it will be hard in Russian Federation, but we have put ourselves in a good position".
"I think we have done enough of a job tonight, there was a good pace in the first half, the two teams gave everything which is why is was such a spectacular first half", he said.
"It's an important achievement to be runner-up in an important competition such as the Champions League but it's always better to be the champion, that's obvious".
The hosts led after eight minutes through captain Senad Lulic, but Valon Berisha equalised with a penalty.
Lazio went back in front when Marco Parolo produced a backheel from a Luis Alberto pass before substitute Takumi Minamino equalized again for Salzburg.
Italy's Lazio ended Salzburg's 35-game unbeaten run stretching back to August after the Austrian side were undone by late goals from Anderson and Immobile.
Timo Werner scored the only goal as RB Leipzig beat Marseille 1-0 in a close first leg.