Opting for first knock, Pakistan effectively batted the reigning World champions out of the contest when they piled up 205 for three from their 20 overs - their highest-ever total in T20 Internationals. Debutant Shaheen Afridi had a wicketless outing.
Fakhar Zaman provided early momentum to the Sarfraz-led team with his 40 runs off 17 balls, including six fours and two sixes on the strike rate of 235.29.
Talat finished with 31, and Asif Ali scored 25 not out as Pakistan chased down the target in 16.5 overs. Emrit and Smith picked up one wicket each for West Indies.
What time does Pakistan vs West Indies 1st T20I start? The toss will take place at 8:00pm PST.
West Indies captain Jason Mohammed was left once again to lament his side's poor performance, after they slipped to a second defeat in as many days here yesterday, to concede the three-match series to Pakistan.
Where can one watch live matches of the series?
"I think I'm pretty much safe in Pakistan ..."
He reached the landmark in just 21 innings to join West Indies great Viv Richards, England's Kevin Pietersen and Jonathan Trott as well as South Africa's Quinton de Kock. Marlon Samuels and Samuel Badree are the only two big names in the visiting side.
Shadab Khan (2-27) cleaned up Samuels in the 12th over and also got rid of debutant Andre McCarthy cheaply before Fletcher fell after hitting three sixes to register his sixth T20I half-century.
Shadab Khan gestures after dismissing Chadwick Walton in the second T20I.