Assuming plans are finalized, the series will be played at Olympic Stadium, which hosted the 2012 Olympics and is now used for soccer and track and field events.
A historic baseball rivalry could be on display over in London, if the deal goes through.
Jacoby Ellsbury was too ill to attend the Boys & Girls Club luncheon on Monday and more than likely will start the season on the disabled list which will create a roster spot for an added pitcher or position player. Compared to other venues which host football, the London Stadium is much wider having catered for a 400m running track during the Olympics which is partly why it was selected by Major League Baseball officials a year ago.
Both Wembley and Twickenham have hosted National Football League games in recent years.
Henry, in an email to The Associated Press, wrote: "This is something the two clubs have discussed for years with Major League Baseball and hopefully it will become a reality".
The most recent collective bargaining agreement between owners and players, which was ratified in 2016, includes a commitment to multiple worldwide destinations.
"I think it would be a lot of fun, to be honest", Yankees first baseman Greg Bird said.
This would be the Yankees' first global regular-season game since 2004 when they opened up the season against the Tampa Bay Rays in Tokyo.
Additional regular-season games were played at Monterrey in 1996 (San Diego-Mets); and at San Juan in 2001 (Toronto-Texas), 2003-04 (a total of 43 Montreal home games) and 2010 (Mets-Florida Marlins).