Apart from a raucous corner behind David de Gea's goal where the Sevilla supporters were housed, the famous stadium was suddenly bereft of belief, the tension that had preceded Ben Yedder's introduction replaced by despair.
Mourinho said three weeks ago that until a team reached the quarter-finals they could not be regarded as genuine Champions League contenders, so by his own admission United have failed after spending so much money on players like Romelu Lukaku and Paul Pogba, the latter of whom did not even start this game and was unimpressive when he came on.
His negative tactics were ultimately undone by Sevilla coach Vincenzo Montella, whose second-half tactical switch, introducing substitute Ben Yedder for Luis Muriel, prove the decisive moment in the game.
- Picture by Action Images via ReutersMANCHESTER, March 14 - Manchester United manager Jose Mourinho insisted European disappointment is nothing new for the English giants after losing 2-1 to Sevilla at Old Trafford to crash out of the Champions League by the same scoreline on aggregate. I sit in the chair with Real Madrid, Man United out.
Manchester City and Liverpool both secured big away wins to put their respective ties to bed with 90 minutes still to play, yet United approached a trip to the Ramon Sanchez Pizjuan with a more safety-first style and secured just a 0-0 draw. "We tried, we lost and that's football".
In the 74th minute, Ben Yedder broke the deadlock just two minutes after coming off the bench.
Mourinho sprang a surprise before kick-off by recalling Marouane Fellaini at the expense of Pogba, who had also been dropped for the first game.
For United, though, they haven't had that luxury at all this season.
"After 10 to 15 minutes, Sevilla has a good team and can hide the ball in midfield".
Ben Yedder received Pablo Sarabia's pass and thumped a finish beyond De Gea for his first, and the goalkeeper - instrumental to United's clean sheet in Seville - could not keep out the striker's back-post header four minutes later.