Police say they were killed when a suspected drunken driver struck them as they stood outside their auto along Interstate 70 on Indianapolis' west side.
Police said Monroe was believed to be a ridesharing driver who was taking Jackson somewhere when he became ill.
President Donald Trump posted two tweets early Tuesday regarding the tragedy, one to touch on illegal immigration and border security, and a second to send condolences to Jackson's family.
Edwin Jackson was 26 at the time of his death.
Orrego-Savala is a Guatemalan national who Immigration and Customs Enforcement believes entered the U.S. illegally in July 2004, spokeswoman Nicole Alberico told The Indianapolis Star.
Before the crash, authorities say Jackson and the other man were stopped on the side of the road; then, they were hit. They were outside of their vehicle when the suspect, Manual Orrego-Savala, plowed into both men in the emergency lane with his Ford F-150.
Orrego-Savala's blood alcohol level was 0.239 at the time of the crash - three times the legal limit - The Indianapolis Star reported, citing a probable cause affidavit. Orrego-Savala was suspected of driving drunk when he slammed into Jackson and Monroe after they pulled over on Interstate 70 in Indiana. And despite so many tragic stories like this occurring on a regular basis, hundreds of cities, counties and states continue to protect criminal illegal aliens like Orrego-Savala. They're working with USA immigration officials, who have placed a hold on Orrego-Savala. A state trooper spotted the wreckage and as he slowed to stop for the crash, he struck the body in the center lane, officials said. This is a time when the entire Colts community needs to come together in support of these victims, and Jim Irsay is leading the way.
Orrego-Savala is due in court Wednesday for a preliminary hearing.
It's unclear when Orrego-Savala entered the United States for the third time, and when he arrived in Indiana. Prosecutors said they were working with police on the investigation. The man, Jose Ines Garcia Zarate, was found not guilty of murder in the case.
The 6-foot, 234-pound Jackson attended Georgia Southern. Monroe and Jackson were pronounced dead at the scene. He was considered a possible starter at inside linebacker for the 2017 season but missed the season after suffering an injury during training camp.