It hasn't quite been a flawless game for Sanchez as he has at times struggled to keep possession, losing it more often on Saturday than any other Red Devils player has all season.
"It is very early, but they look to have the quality to integrate into the game we want to play", Wenger said of Aubameyang and Mkhitaryan.
"The two players [Aubameyang and Mkhitaryan] integrated well [into] our game and looked like they had played with us forever", Wenger admitted.
The former Manchester United man, who joined in January in a swap deal for Alexis Sanchez, set up Ramsey in the opening six minutes before teeing up debutant Pierre-Emerick Aubameyang and later laying on a pass for Ramsey to sweep home for his treble.
A wave of optimism swept over the stadium before kick-off and it propelled Arsenal to a resounding victory, with the hosts hammering four goals past Jordan Pickford in the first half alone. However, the substitution of key players caused a bit of a stir amongst the Arsenal faithful.
"It is football, and whatever formation you play, or whichever personnel are in the team, you have to do your best", he added.
"This was just the first game, against a good team, away, and of course it was tough for the team but I'm sure we will improve our game and have some good results for the future".
Mkhitaryan, on eight, now has more than twice as many assists as Sanchez (3) in the league this season and is just one behind United's best player for setting up goals this term: Paul Pogba, who is on nine.
Henrikh Mkhitaryan and Pierre-Emerick Aubameyang celebrate after the match.
But it is the form of the new arrivals that will have Arsenal fans the most excited. Apart from the highly-anticipated debuts, it was Aaron Ramsey who ran riots in the middle of the field and single-handedly demolished the Toffees bagging himself a hat-trick of goals. "He was involved in the link-up play as well, so we're definitely happy to have him and we can't wait to see what he brings to the team", Super Eagles star Iwobi added.