Members of the Florida Congressional Delegation have been among the staunchest Trump White House defenders, and the first to respond was Pensacola Rep. Matt Gaetz.
Trump's campaign is being investigated for possible collusion with Russian Federation.
He was eligible to retire in March, but with his accumulated leave, he is able to step down earlier.
The White House was not involved in McCabe's decision, press secretary Sarah Huckabee Sanders told reporters Monday afternoon.
US media reported the resignation early on Monday afternoon, citing staff sources at the bureau.
Republicans have criticized McCabe in connection with the FBI's investigation into Clinton's use of a private email server while she served as USA secretary of state.
Trump also targeted McCabe for the FBI's investigation into 2016 Democratic presidential candidate Hillary Clinton's use of a private email server while serving as the country's secretary of state.
Former Attorney General Eric Holder tweeted Monday that McCabe "is, and has been, a dedicated public servant who has served this country well". The FBI has said McCabe received the necessary ethics approval before his wife received the donations.
Trump's not-involvement dates back at least to May, when, according to Washington Post, he asked McCabe who he voted for in the presidential election. In December, McCabe was grilled behind closed doors by lawmakers on some of those panels for hours.
Fox News reports that FBI Director Christopher Wray went to the Capitol yesterday to view the House Intelligence Committee's memo. His wife's run for office also started months before he had any role in the Clinton probe.
It was reported last week that the classified four-page memo alleges that McCabe and other Federal Bureau of Investigation and DOJ officials were involved in those alleged abuses.
Republicans have seized on text messages exchanged between the two as evidence of bias.
Strzok and Page used words like "idiot" and "loathsome human" to describe Trump during the campaign. Page left the investigatory team after her 45-day detail ended in July.