Arsenal have not beaten third-placed Tottenham in the last six league meetings but Wenger remains confident they can beat their local rivals. For what seems like the first time in decades, Tottenham is widely regarded as a clear favorite even though the match is taking place at Arsenal's Emirates Stadium.
How should Arsenal line up against Tottenham on Saturday?
And ahead of Saturday's derby, Piers Morgan, an avid Arsenal fan, has delivered a sensational message to Harry Kane.
He has gone from strength to strength ever since, having won the Premier League Golden Boot in the past two seasons with 25 goals in 2015/2016, and 29 goals in 2016/2017.
"Not at all. I think Tottenham is a good side but we have the quality to win this game and that is what we want to show", he told reporters.
Wenger is hopeful the 32-year-old will return in January. That might not happen this season.
It means the manager, who has not lost a league game against Arsene Wenger in his three years at the helm, will have to decide whether to give youngster Harry Winks a starting place in place of the more experienced Mousa Dembele and whether Danny Rose has done enough to push Ben Davies out of the side. It was five years ago (almost to the day) that the Gunners ran five past their rivals in a thrilling show at the Emirates that ended in a 5-2 win. We were under pressure the last couple of years, with people talking about winning trophies.
"It is a massive challenge to.be competitive against a team that in last 20 years won more trophies than us".
Arsenal last thumped Tottenham?
Arsenal will be without injured striker Olivier Giroud, while Wenger has to decide whether to recall Alexandre Lacazette to the team after leaving the France worldwide out of two big games this season already, at Liverpool and Man City.
Arsenal's record signing has only completed 90 minutes once since his summer arrival but Wenger says there is no lack of trust.