Mane will reportedly not be considered for Saturday's Premier League meeting with West Ham United, with his comeback drafted in for the game against former club Southampton at Anfield after the worldwide break on November 18.
They know, however, that defeat will further harm their chances of securing Champions League football for next season. It's going to be a hard game. If that pressure isn't bad enough, he'll somehow have to navigate a Liverpool attack that's once again finding it's stride with a depleted back-line.
Jose Fonte, James Collins (both foot) and Pablo Zabaleta (suspension) are also unavailable.
Although they've only lost two out of their last nine outings, the Hammers need to start putting real points on the board if they're going to climb their way in to the right half of the table.
Considering the Reds have conceded an embarrassing 15-goals on the road, it's hard to see how they're going turn it around at the London Stadium.
Liverpool ended a three-game winless run in the Premier League with a 3-0 victory over Huddersfield Town at Anfield last weekend thanks to goals from Daniel Sturridge, Roberto Firmino and Georginio Wijnaldum. "They bring a lot with them, they have great support, great players and an exciting manager in Jurgen Klopp".
Winston Reid and Aaron Cresswell have eased West Ham United's defensive injury concerns by being available for Saturday evening's home match with Liverpool.
West Ham have endured a woeful start to their 2017/18 campaign, and now sit in 16th position in the Premier League table, after a return of just nine points from their opening 10 league outings.