Veteran Ortiz was pencilled in to challenge WBC heavyweight title holder Deontay Wilder on November 4, although an adverse finding was flagged earlier this week.
Wilder began his reign in January 2015 by taking the WBC crown with a unanimous decision triumph over Stiverne in Las Vegas.
Stiverne is a replacement for Luis Ortiz, who was forced to drop out after he failed a drug test and forced the WBC to remove its sanction of the fight. Ortiz, who in 2014 was suspended for a positive steroid test, was found to have taken two banned diuretics that are often used as masking agents for steroids.
Stiverne, who was ranked No 1 challenger by the WBC was due to take on Anthony Joshua victim Dominic Breazeale, with the victor to fight Wilder. Showtime will televise the contest. A risky bout against Alexander Povetkin previous year was canceled when Povetkin also failed a random pre-fight VADA test for a banned substance.
Stiverne has been the only man to last the full distance with Wilder, but the champion is promising that he'll never see the final bell when they meet for a second time.
A victory for Wilder could set the stage for a 2018 unification showdown against the reigning IBF and WBA champ Anthony Joshua, who is 19-0 with every win by knockout. "That was a lot of the reason why it went the distance", said Wilder. "This time it won't end well for him". "On Nov. 4, Wilder will feel my pain". "It was my fault, but I learn from my mistakes".
Promoter Lou DiBella would have preferred to put on Wilder against Ortiz, but he is also rolling with the punches of the late change.