The State Department also warned that US citizens have been murdered in carjackings and highway robberies, with victims stopped by roadblocks or being run off the road. This new warning replaces a travel warning that was issued for the country on December 8, 2016.
Gun battles between rival criminal groups or with Mexican authorities have taken place on streets and in public places during broad daylight, officials said.
The warning followed another US advisory that tainted alcohol at resorts in Mexico may be linked to numerous reports of death, blackouts, injuries and illnesses among American tourists.
"While most of these homicides appeared to be targeted criminal organization assassinations, turf battles between criminal groups have resulted in violent crime in areas frequented by US citizens", the department writes of both states, as well as of Baja California.
Yet tourist meccas like the beach resorts of Quintana Roo and Baja California Sur have the potential to be hard hit by such injunctions.
The U.S. State Department has released an updated travel advisory for Mexico, expanding its warnings specifically about the regions home to some of the country's most popular tourist destinations.
The State Department has outlined an assessment for each state in Mexico, with specifics on the advisory for each area.
"Shooting incidents, in which innocent bystanders have been injured or killed, have occurred" in both states, the warning said.
Quintana Roo's Tourism Ministry was quick to respond to the advisory, issuing a statement to say travelers to the state are "safe and protected" and the government will keep collaborating with federal and USA officials on security.
The state of Quintana Roo, where the resorts of Tulum and Cozumel are also located, gets 10 million tourists a year, a third of the national total.
The agreement is the second to be achieved Mexico after Mexico City, however, Airbnb in Jalisco, Baja California and Nuevo Leon are expecting to do the same in coming weeks.