Defeat by Tottenham ended Mourinho's hopes of his team catching Manchester City for fourth, and qualification for the Champions League next season.
Paul Pogba will not be back for Manchester United's Premier League contest against Southampton on Wednesday, but Jose Mourinho will resist the temptation to play the "kids".
"I want to think about the final I have to play", Mourinho told Sky Sports before hurrying off.
Mourinho has been a constant critic of the fixture schedule this season, with runs in the FA Cup and Europa League adding to 38 Premier League games.
"Because if I have Ashley Young, Luke Shaw, Marcos Rojo, (Zlatan) Ibrahimovic, Tim Fosu-Mensah, if I had these guys I can rotate, I can go for every match".
"If I only have 14 or 15 players, I can't do it". It's as simple as that.
"It's true that the calendar has been hectic over the last two months, but we have to push hard now to try to win the three remaining games".
"As players we don't want to be sitting on the touchline or watching the games in the directors' box".
"The most important thing for us is no injuries, and some people having a proper rest". I can not lose 5-0 or 6-0.
However, ultimately, the Red Devils couldn't muster another goal before the final whistle - making it four games without a Premier League win for United.
"It does eat away at you", Smalling said aboutnot finishing in the top four.
"And another team (United) trying to find some balance even with players, some of them not playing in their best positions".
"The two goals conceded were bad".
For the first time ever the UEFA Champions League final will also be available through a number of 360°streams on YouTube and the new BT Sport Virtual Reality App, allowing viewers to choose between a 360°produced programme with commentary and graphics, or select their own camera viewpoint.
"We look forward to a strong finish to 2016-17, both on and off the pitch", said Executive Vice Chairman Ed Woodward.
The Premier League side, under the guidance of Jose Mourinho, face Ajax on 24 May, with the victor securing €6.5m (£5.6m) and a place in next season's Champions League - Europe's most lucrative club competition. "The facilities on the training ground and the stadium will put the team and the club at the last level".