United were the opposition for the 2,533rd match at White Hart Lane, 118 years after Tottenham first hosted Notts County here and won the game 4-1.
Mauricio Pochettino's Tottenham Hotspur side are now second in the Premier League table with 77 points from 35 games this season, coming off the back of five wins from their last six outings.
While a win over the current Manchester United side might not be as famous as one against them in previous meetings, there's no denying that the Tottenham Hotspur supporters have been privy to some memorable - and heartbreaking - moments at White Hart Lane. Marouane Fellaini is suspended for the match as well, and Paul Pogba will also be absent after he returned home following the death of his father.
The stadium, home since 1899 and already being swallowed up by the new 61,00-seater ground rising around it, will be demolished with the club playing at Wembley next season before returning in the 2018-19 campaign.
"It is fantastic to achieve second position", he told Sky Sports.
Spurs fans arrived to white commemorative t-shirts and flags hanging from their seats while the team wore special edition matchday shirts, emblazoned with a one-off White Hart Lane crest.
José Mourinho will likely follow through on his promise to rotate key players for the remaining league matches of the season. It will be the last Spurs match at the old stadium, a new stadium is being built on the site.
Harry Kane has scored against 23 of the 25 clubs he has faced with Tottenham in the Premier League - though he's yet to score in six appearances against United. This is, however, their first second-place finish - and the only time they have gone an entire season without losing at home - since Bill Nicholson was manager in the 1960s.
"Sure it will be very, very emotional but at the same time it will be exciting to welcome the new stadium".
"We will make Wembley our home and we will start to feel very comfortable there", he said. Instead of joining the sentimental masses, we're choosing to focus on the tactics of the match itself.
Manchester United travel to White Hart Lane to take on Tottenham in the Premier League.
The Red Devils need victory at the Lane farewell to keep their hopes of finishing in the top four alive, after Arsenal moved four points ahead of them in fifth, and a point behind fourth-placed Liverpool, with the victory over Stoke. We have played so many matches because we progressed to two finals and the last 16 in the FA Cup. Four of the seven games have finished 0-0.