Britons Geraint Thomas and Adam Yates saw their hopes of Giro d'Italia victory disappear after a police motorbike caused them to crash on Sunday's ninth stage, which was won by Nairo Quintana.
That belonged to the stationary police bike that was not parked far enough off the road and clipped the Dutchman, sending him into the peloton.
The crash which occurred at the summit of the final climb left most of Team Sky panned out on the ground and had a major impact on the stage results.
Thomas appeared to be suffering from a right shoulder injury and stayed down for several minutes before being able to get back on his bike. "It's ridiculous. My shoulder popped out".
Quintana went on to stamp his authority on the general classification, claiming the overall lead on the first big mountain stage.
The Movistar rider finished 24 seconds in front of FDJ's Thibaut Pinot and Team Sunweb's Tom Dumoulin to take top spot from Luxembourg's Bob Jungels. I'm very happy that I won.
Yates finished about 4 1/2 minutes behind and Thomas crossed more than five minutes back.
Another Dutchman, Bauke Mollema (Trek-Segafredo), who was fourth on the day, is fourth overall 51 seconds off the pace and fifth-placed Nibali is 1:10 behind Quintana. "The whole team was strong and I was strong".
"I felt good, then I crashed".
Nibali was fifth, 59 seconds behind Quintana.
In a tough finale, there was heartbreak for Conti as his bike slid from beneath him on a hairpin bend on the climb to the finish inside the final kilometre and it was Izagirre who rode away to victory and join his brother Ion as a Grand Tour stage victor, with Visconti second and Sanchez third.
In the overall standings, Quintana leads Pinot by 28 seconds and Dumoulin by 30 seconds.
Thomas and Yates will have a rest day on Monday to consider their options, the British duo getting much-needed time to rest their tired and battered limbs ahead of stage 10 on Tuesday.