But all eyes will be on Jesus and what role he may play, with Guardiola taking a decision after the team has travelled to London.
"He's really, really much, much better".
He will once again be without young centre-back John Stones, who has a muscle injury, but Brazilian starlet Gabriel Jesus is in contention to play as he returns to action. "We are going to travel, all the group, to Wembley, he will be part of that and after that we'll see".
The first semi-final sees Chelsea meet Tottenham in a battle between the current Premier League top two.
His return will be a welcome boost for City as they look to finish the season on a high.
Arsenal must face Manchester City on Sunday without injured quintet Shkodran Mustafi, Danny Welbeck, Lucas Perez, David Ospina and Santi Cazorla.
Defensively, Guardiola has tinkered repeatedly with formation and personnel, overlooking a fully-fit Vincent Kompany for the second-leg against Monaco when his experience could have been crucial, while the early season stand-off with Yaya Toure that led to the midfielder's prolonged absence ultimately only hurt the team. "We are not in a position to chose this or that".
"When you have negative results like we had it can divide or unite", he said. "We are ambitious, we have done it before, we know we can do it, but in the previous semis we were favourites so the problem was different". "What we have to do in the next years, nothing changes if we win or don't win the title".
If this weekend comes too soon for Gabriel Jesus, Guardiola's team selection for Thursday's Manchester derby against United in the Premier League will be fascinating.
The man himself is fairly phlegmatic about it all heading into an FA Cup semifinal against Arsenal at Wembley Stadium on Sunday.
They've also won the trophy 12 times, a joint-record alongside Manchester United. Their last defeat at this stage was in 1932 against Arsenal.
It seems the claw-back at the Emirates had semi-galvanized a dwindling season for the Gunners, picking up six points out of their last three encounters with a 3:0 win in the league against a Mid-table "Hammers" side. If he wants to, he'll have to ensure his charges dispatch Arsenal first.
Brazilian global Jesus, who made an instant impact after joining City in January with three goals in four league games, returned to training earlier this month after suffering a foot injury against Bournemouth in February.
Finally, Wenger also gave the following update on Jack Wilshere.